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This book constitutes the refereed proceedings of the 15th International Conference on Health Information Science, HIS 2026, held in Haikou, China, during November 11–14, 2026. The 18 full papers and 9 short papers included in this volume were carefully reviewed and selected from 68 submissions. The scope of the conference includes: (1) medical/health/biomedicine information resources, such as patient medical records, devices and equipment, software and tools to capture, store, retrieve, process, analyze, and optimize the use of information in the health domain; (2) data management, data mining, and knowledge discovery, all of which play a key role in decision-making, management of public health, examination of standards, and privacy and security issues; (3) computer visualization and artificial intelligence for computer-aided diagnosis; and (4) development of new architectures and applications for health information systems.