{"product_id":"retinal-degenerative-diseases-xx-ebook","title":"Retinal Degenerative Diseases XX","description":"\u003cp\u003e\u003cstrong\u003ePart I: Age-Related Macular Degeneration (AMD)\u003c\/strong\u003e.- Associations of the adaptive immune system and age-related macular degeneration.- Macrophages and and age-related macular degeneration.- RPE basal lamina biology and pathophysiology related to age-related macular degeneration.- Genotype-Phenotype Correlations and Genetic Risk Assessment in Age-Related Macular Degeneration.- Photoreceptor degeneration: more than a bystander in age-related macular degeneration.- Cellular Senescence–an emerging player in the pathogenesis of AMD.- \u003cstrong\u003ePart II - Inherited Retinal Degenerations\u003c\/strong\u003e.- Novel Potentially Pathogenic Variants in TBC1D32 cause Non-syndromic Rod-Cone Degeneration.- The BXD32 Mouse: A High-Fidelity Model of Chronic Retinal Inflammation and Photoreceptor Degeneration.- The challenge of VUS in inherited retinal degeneration: insight from functional studies.- ABCA4 c.5461-6T\u0026gt;C causes Stargardt disease through exon skipping.- Assessment of ABCA4 Genetic Variants: Current Landscape and Future Prospects.- Exploring the Role of ABCA4’s ECD2 Domain in Inherited Retinal Degeneration: Computational and Functional Perspectives.- MFRP in early-onset retinal degeneration: Clinical and Molecular Perspectives.- Genetic Landscape of Non-syndromic Retinitis Pigmentosa in Portugal.- Part III: Gene Therapy and Gene Editing.- Frequency and Pattern of Gene Therapy Clinical Trials for Inherited Retinal Diseases.- CRISPR\/Cas-mediated gene activation as a versatile tool for treatment of inherited retinal dystrophies.- Prime Editing Strategy to Install the RPE65 c.1430A\u0026gt;G Dominant Mutation.- Megabase deletion of the human EYS locus using CRISPR\/Cas9.- Prime Editing Strategy to Install the Mfrp Retinal Degeneration 6 mutation.- Precise Gene Editing Technologies In Retinal Applications.- \u003cstrong\u003ePart IV: Immunity and Inflammation\u003c\/strong\u003e.- Current perspectives of TLR2 signalling in the retina.- Monocytes in Retinal Degeneration: Little Cells with a Big Impact.- Understanding the different microglia functional states to modulate their activity in retinal degeneration.- Progress in assessing retinal microglia using single-cell RNA sequencing.- The Role of Microglia in Glaucomatous Pathology.- \u003cstrong\u003ePart V: In-Vivo Imaging for Structure and Function\u003c\/strong\u003e.- Non-invasive assessment of ocular structure in the elderly 13-lined ground squirrel.- \u003cstrong\u003ePart VI: Mechanisms of Degeneration.-\u003c\/strong\u003e Potential Role of NUR77 in the Aging Retinal Pigment Epithelium and Age-Related Macular Degeneration.- Identification of unexpected pathomechanisms underlying the human Usher syndrome.- The loss of Usher II proteins in mice does not affect photoreceptor ultrastructure.- A role for SARM1 in photoreceptor cell death.- Exploring Histone Modifications in Inherited Retinal Disorders.- Effect of photobiomodulation on proliferative changes in the retina: Evidence from an in vitro model of PVR.- \u003cstrong\u003ePart VII: Mechanisms of Degeneration\u003c\/strong\u003e - Animal Models.- Calcium binding protein 4 is fundamental for retinal structure and function.- Association between C22:5-containing lipids and RPE Pathologies in Mice with Tmem135 Overexpression.- Extracellular Matrix Gene Expression Patterns in Retinal Wound Healing: A Comparative Study between Mouse and Zebrafish Laser Injury Models.- Zebrafish as a Model for Stargardt Disease.- Fish models of ageing retinal disease.- The power of zebrafish in disease modeling and therapy discovery for inherited retinal degeneration.- Unexpected retinal abnormalities in the cone-dominant northern tree shrew.- Deletion of Pnpla2 Causes Malformation and Malperformance of Mouse Photoreceptors.- Light as a mediator of acute and chronic retina degeneration.- A Knockin Model with the mouse equivalent to the c.2299delG Mutation in usherin Exhibits Early-Onset Hearing Loss and Progressive Retinal Degeneration.- Oxidative stress and energetic failure: common features and dissimilarities in 3 different mouse models of retinal pigment epithelium phagocytosis defects.- \u003cstrong\u003ePart VIII: Mechanisms of Degeneration – Metabolism\u003c\/strong\u003e.- The connection between cellular metabolism and retinal disease.- Stimulation of Thyroid Hormone Signaling Induces Stress Responses in Mouse Retina.- Ocular Tissue-Specific Amino Acid Metabolism in Gyrate Atrophy.- \u003cstrong\u003ePart IX: Neuroprotection\u003c\/strong\u003e.- Is Caveolin-1 required for retinal neuroprotection?.- Brain-derived neurotrophic factor in retinal integrity under diabetic and hypoxic conditions.- \u003cstrong\u003ePart X_  Photoreceptors\u003c\/strong\u003e.- Girdin is a Class I Phosphatidylinositol 3-kinase Binding Protein in the Retina.- Photoreceptor disc morphogenesis: who are the conductors of this highly metronomic process?.- Mechanism of photoreceptor outer segment tip ingestion: Evidence of trogocytosis.- The PRPH2 D2 Loop: Biochemical Insights and Implications in Disease.- Vulnerability of the Nrl−\/− Cone-Dominant Retina to Endoplasmic Reticulum Stress.- Molecular components of vesicle cycling at the rod photoreceptor ribbon synapse.- \u003cstrong\u003ePart XI: RPE\u003c\/strong\u003e.- Less is more: the RPE cell culture medium additive THT mildly impairs RPE health.- Desmosome and Hemidesmosome Disassembly in Retinal Pigmented Epithelium – Intersection with the Exosome Pathway.- Signaling pathways in Retinal Pigment Epithelium (RPE) cells in response to stress conditions of Age-Related Macular Degeneration (AMD).- The Importance of Differentiated RPE Cultures to Study Cell Biological Processes.- IGFBP5 as a Novel Basolateral Secretion Marker in the Retinal Pigment Epithelium.- Role of microsomal triglyceride transfer protein (MTP) in lipid processing pathways in retinal pigment epithelium.- Immunogenic switch of RPE cells.- Mitochondrial DNA Damage in the retinal pigmented epithelium (RPE) and its role in RPE pathobiology.- \u003cstrong\u003ePart XII: Stem Cell Models and Therapies\u003c\/strong\u003e.- Live imaging microscopy of human retina organoids: Photoreceptor pathology.- The Importance of Choriocapillaris Replacement in Therapeutic Strategies for Age-Related Macular Degeneration.- Classifying Mouse RPE Morphometric Heterogeneity Using REShAPE – an AI-based Image Analysis Tool.- Dysregulation of Retinal and Photoreceptor Structural Integrity Genes in ATF6-\/- Retinal Organoids.- Engineering specific human iPS reporter cell lines to generate optogenetically modified photoreceptors.- \u003cstrong\u003ePart XIII: Retinal Cell Biology\u003c\/strong\u003e.- Phosphoinositide 3-Kinase Enhancer Protein: Insights into its Expression and Functions in Retinal Cells.- Expression of Versican in the retina and its implication in retinal disease.- The role of RPE phagocytosis in the retina metabolic ecosystem.- Ocular Localization of Complement Factor H and its Association with Diseases in the Eye.- The Role of Primary Cilia in the Eye.- Key Claudins at the Blood-Retina Barriers.- NUDC is Critical for Mitosis and Postmitotic Cell Maintenance Through its Modulation of Dynein and Actin Cytoskeletal Reorganization.- Interplay of Retinal and Choroidal Vasculatures in Ocular Health and Disease.- Genetically encoded metabolic sensors to study retina metabolism.- Riboflavin, retbindin and riboflavin transporters in the retina.- Critical Roles of SEA Domains.- \u003cstrong\u003ePart XIV: Drug and Other Therapies\u003c\/strong\u003e.- Targeting connexins biology as therapeutic strategies against retinal diseases.- Uncovering Novel Drugs that Restore Vision Using Orthogonal Pooling in Zebrafish.- Steroid-Nitroxide Hybrid Compound Protects the Retina in a Model of CNV.- \u003cstrong\u003ePart XV: Human Studies\u003c\/strong\u003e.- Artificial Intelligence-assisted Matching of Human Postmortem Donors to Ocular Research Projects.- Late-Onset Retinal Degeneration: clinical features and C1QTNF5\/CTRP5 function.\u003c\/p\u003e","brand":"Catherine Bowes Rickman","offers":[{"title":"Default Title","offer_id":53651647168839,"sku":"9783031765506","price":373.43,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0920\/5455\/2903\/files\/retinal-degenerative-diseases-xx-ebook-cover.webp?v=1775337590","url":"https:\/\/www.cinebuch.de\/products\/retinal-degenerative-diseases-xx-ebook","provider":"CineBuch","version":"1.0","type":"link"}